Endocrine Abstracts

Introduction: Phthalates are ubiquitous endocrine disruptors (EDs). EDs induce obesity. MEP and MEHP affect thyroid function.Aim: Estimation of burden of MEP and MEHP in our population, evaluation of leptin in obese MEP and MEHP positive and negative subjects and evaluation of connection between leptin, MEP, MEHP and thyroid indicators in that subgroup. Materials and methods: a cross-sectional study, with 201 subjects divided into MEP/MEHP positive and n...

The data of etiology and clinical characteristics of hypopituitarism in different countries differes. The aim of the study is to investigate etiology and some clinical characteristics of patients with hypopituitarism that were treated in the Clinical center of Vojvodina. The study was conducted as a retrospective study. There were 32 males and 28 female patients. Mean age was 52.2±17.5 years. Data was analized before and after substitution of hypopituitarism. Patients wer...

Introduction: Long-term therapy with bisphosphonates is considered a risk factor for the development of atypical fractures of the femur. One of the mechanisms of these fractures is excessive suppression of bone metabolism. The supplementation dose of vitamin D and calcium could have an impact on the degree of suppression of bone turnover.The aim: To determine whether the presence or dose of supplementation with vitamin D and calcium during antiresorptive...

Several studies have pointed to increased morbidity and mortality in patients with hypopituitarism, particularly from cardiovascular diseases, regardless of the application of the substitution therapy. The aim of this study was to present clinical characteristics and cardiovascular risk of our patients with hypopituitarism during 20 years of follow-up.Methods: Sixty patients with hypopituitarism without patients with acromegaly and Cushing disease were a...

Primary hyperparathyroidism is an autonomous form of hyperparathyroidism, whose characteristics are: increased secretion of parathyroid hormone with clinical signs of hypercalcemic syndrome and various organ lesions, including bones.Case report: A 51-year-old Caucasian female presented with walking difficulties, polyuria, polydipsia, palpitations and headaches. Examination showed thoracic spine hyperkyphosis with consecutive chest deformity, staggered wa...

Metabolic and immunological disturbances may be associated with hyperprolactinemia.Aim: The aim of this study was examination the presence of some metabolic and immunological disturbances, like as the changes in and body composition, as risk factors for development of atherosclerosis, in young women with hyperprolactinemia.Material and methods: The investigation was performed as prospective study in a group of 20 premenopausal wome...

Adrenal tumours form a very heterogeneous group by their origin, clinical presentation, size and biological potential.The aim of our retrospective study was the epidemiological analysis of the patients with adrenal tumours. We analyzed the gender, age, localisation, clinical presentation, and in patients who were treated surgically- the type of the intervention, patohystological and immunohystochemical finding from the 01.01.2000 to 01.01.2008. The linea...

Background and aims: Foot lesions (amputations, ulcerations) are the consequence of neuro-vascular complications. Cardiovascular risk factors are similar for both. Thus, we carried out a prospective 5-year study to examine the effects of established complications and classical risk factors on mortality in diabetic patients.Materials and methods: During the previous 5 years we analyzed 244 patients attending a diabetes clinic. The International Working Gr...

Introduction: Biological casuses of levothyroxine (LT4) malabsorption are well known. Congestive heart failure, gastrointestinal diseases, pregnancy, medication or dietary interference are the most commonly known causes of poor oral absorption of LT4. However, when substitution therapy with LT4 fails we need to be more exploratory.Case description: Female, born in 1987, BH 164 cm, BW 73kg, in 2010 she was presented as M. Basedowi and in october 2011 near...

Introduction: The impairment of liver function and enhancement for NAFLD development may be attributed to the ubiquitous exposure to endocrine disrupting chemicals such as phthalates. In this study the urinary levels of monoethyl phthalate (MEP) and mono-(2-ethylhexyl) phthalate (MEHP) were compared with the parameters of hepatic function and lipids in overweight, diabetic patients and normal weight population.Methods and patients: In 305 volunteers of b...